In order to study the effect of cytokinin, gibberellin and cycocle on yield and yield components of two wheat cultivars under different irrigation regimes, a study was conducted as a split-split experiment based on a randomized complete block design with three replications at the Agricultural Research Station of Kurdistan University in 2016. irrigation factor at four levels: dryland, irrigation at booting stage, irrigation at booting + flowering and irrigation at booting + flowering + grain filling stages as the main plots, two wheat cultivars (Sirvan and Homa) as sub-plots and levels of plant growth regulators foliar application including: control, gibberellin (100 µm), cytokinin (100 µm) and cycocel (3gr. lit-1) at the wheat stem elongation and grain filling stages as the sub-sub plots were considered. The results showed that in the foliar application during the stem stage, compared to the dryland treatment, yield increase in one, two and three irrigation treatments were 29, 33 and 43 percent, and at the grain filling stage were 22, 28 and 33 percent, respectively. Homa cultivar produced higher yield compared to Sirvan. in the foliar application during the stem stage, the highest grain yield (504 g m-2) was obtained under three irrigation treatments and application of cytokinin, and at the grain filling stage, the highest grain yield (477.6 g m-2) was obtained from Homa cultivar under three times irrigation condition and cycocel consumption. Therefore, using even one stage irrigation and the application of cytokinin and cycocel can increase the grain yield of wheat.