This study was conducted to investigate the effect of application of humic acid and seaweed extract on morphology, growth, yield and yield components of quinoa under drought stress in 2018-2019 in two different locations, Qasr Shirin and Dalahou. This study was performed as split plots with a randomized complete block design with 4 replications. Experimental treatments include three irrigation treatments (full irrigation, irrigation cut- off at the beginning of flowering and irrigation cut- off at the beginning of seed growth) and foliar spraying treatments with different amounts of humic acid and seaweed extract along with a control treatment. The results showed that seed yield in Dalahou region under no drought stress was 24.78% higher than Qasrshirin region. Seed yield in different irrigation treatments under the influence of foliar application showed that in all irrigation treatments, the effect of foliar application of humic acid and algae extract on seed yield was positive compared to the control. In full irrigation conditions, the highest seed yield was obtained by foliar application of humic acid, while in irrigation cut-off treatments, the effect of seaweed extract on seed yield was better than humic acid. The results showed that the weight of 1000 seeds in quinoa produced in Dalahu region was more than Qasrshirin region but in both regions drought stress caused a decrease in 1000 weight seeds. In all irrigation treatments, application of humic acid and algae extract increased 1000-seed weight.