To evaluate the production of mashhadi melon (Khatouni cultivar) under the different management of fertilizer levels and vermicompost bed, this study was conducted as a factorial experiment in the form of a randomized complete block design with three replications during the spring of 2020 crop year as two separate designs in Fariman and Zahak counties. Application of fertilizers in six levels include non-use of fertilizer (control), cow manure, sheep manure, nanobiomic foliar application, silicone foliar application, and complete application of chemical fertilizer as the first factor and four different levels of vermicompost include non-use of vermicompost (control), 5, 10 and 15 tons per hectare as the second factor. Results showed that the highest fruit yield, total titration, percentage of nitrogen, phosphorus, fruit potassium, and fruit flesh thickness in both Fariman and Zahak counties was obtained from nanobiomic foliar application under 15 tons per hectare of vermicompost. Also, the highest percentage of total soluble solids in Fariman county was observed jointly in the treatment of sheep manure and the treatment of chemical fertilizers and Zahak county in the treatment of non-use of fertilizer (control) under 10 tons per hectare of vermicompost. In Fariman county, the results of cow manure, sheep manure, nanobiomic, silicon, and chemical fertilizers at the levels of 10 tons and 15 tons per hectare of vermicompost did not show significant differences. Therefore, with less consumption of vermicompost, nanobiomic foliar application under 10 tons per hectare of vermicompost is recommended for melon cultivation in Fariman county.